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NSC 234714
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DeCS
Descriptor
English
:
Aphidicolin
Descriptor
Spanish
:
Afidicolina
Descriptor
Portuguese
:
Afidicolina
Synonyms
English
:
Aphidicolin, (3-S-(3alpha,4beta,4abeta,6aalpha,8alpha,9alpha,11aalpha,11balpha))-Isomer
ICI 69653
ICI-69653
ICI69653
NSC 234714
NSC 351140
NSC-234714
NSC-351140
NSC234714
NSC351140
Tree Number:
D02.455.849.291.075
Definition
English
:
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the
growth
of
eukaryotic cells
and certain animal
viruses
by selectively inhibiting the cellular replication of
DNA polymerase II
or the viral-induced DNA polymerases. The drug may be useful for controlling excessive
cell proliferation
in
patients
with cancer,
psoriasis
or other
dermatitis
with little or no adverse effect upon non-multiplying cells.
Pharmacological Action:
Antiviral Agents
Enzyme Inhibitors
History Note
English
:
92; was APHIDICOLIN (NM) 1974-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30254
Unique Identifier:
D016590
Occurrence in VHL
:
Similar:
DeCS